Dosis obat ini diberikan sesuai kondisi klinis dan respon pengobatan, serta pada anakanak berdasarkan berat badan. Acyclovir, 92hydroxyethoxymethylguanine, is an acyclic nucleoside analogue which has a high activity and selectivity for herpes viruses, particularly herpes simplex viruses types 1 and 2 and varicella zoster virus. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral dna polymerase by incorporating into the. A case reporthighlighting the importance of prevention, detection, and treatment of acyclovirinduced nephropathy. An overview of the mechanisms of action of and resistance to acyclovir and its major clinical uses will be provided here. Acyclovir sirolimus sirolimus may cause kidney problems, and combining it with other medications that can also affect the kidney such as acyclovir may increase that risk. Zovirax capsules, tablets, and suspension are formulations for oral administration. The enzyme phosphorylates acyclovir to a monophosphate. Dosage adjustment is required in patients with renal failure. The drug and its metabolites are excreted by the kidney via glomerular filtration and tubular secretion. Aciclovir indications, posologie et effets secondaires. Safety and tolerance studies in animals and humans have shown acyclovir to be very well tolerated. Dosing and treatment of the specific clinical syndromes are described in greater. Acyclovir is selectively acted upon by the viral thymidine kinase.
The drug may be administered topically to the skin, intravenously, orally, or topically to the. Acyclovir is an antiviral drug used mainly for herpes zoster infection. Minum obat acyclovir setelah makan untuk mengurangi efek mual, biasanya diminum 25 kali perhari tergantung dari saran yang diberikan dokter. But patient may need a dose adjustment or more frequent monitoring by his doctor to safely use both medications. It slows the growth and spread of the herpes virus to help the body fight the infection. Plasma protein binding is relatively low at 9 to 24%.
Do not administer acyclovir injectable topically, im, subcut, po, or in the eye. Reconstitute 500mg or 1g vial with 10 ml or 20 ml, respectively, of sterile water for injection. The biochemistry and mechanism of action of acyclovir. Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus dna polymerase. Each capsule of zovirax contains 200 mg of acyclovir and the inactive ingredients. Acyclovir termasuk obat dapat diberikan dengan resep dokter. Valacyclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles herpes zoster in adults valacyclovir is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least. This selectivity is due to the initial activation of the drug.
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